POLYNUCLEOTIDES

Polynucleotides: Transformative Skin Rejuvenation

Polynucleotides are injectable serums derived from salmon or trout sperm DNA. These remarkable molecules mimic human DNA and function as messenger proteins.

Polynucleotides interact with cells, enhancing the production of fibroblasts. These fibroblasts are responsible for generating essential proteins like collagen, elastin, and hyaluronic acid—all crucial for resilient skin.

​Skin Concerns Benefiting from Polynucleotides:

Polynucleotides (PNs) offer a versatile solution for various skin concerns:

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Under-Eye Area:

• Tear Trough: Improves hollows and sagging.

• Dark Circles: Brightens and firms delicate skin.

• Sagging Skin: Lifts and revitalises.

Scars and Pigmentation:

• Lumpy or Sunken Scars: Smoothes and refines scar tissue.

• Acne Scarring: Reduces the appearance of acne scars.

• Hyperpigmentation and Melasma: Helps even out skin tone.

• Rosacea: Calms inflammation.

General Signs of Facial Aging:

• Wrinkles and Fine Lines: Softens and rejuvenates.

• Eyebrow and Scalp Hair Loss: Stimulates hair follicles.

• Neck, Décolleté, Inner Arms, Thighs, and Knees: Enhances skin quality and thickness.

 

Results and Timeline:

• Gradual Improvement: Results unfold over a few months.

• Reduced Pigmentation: Skin becomes clearer and more even.

• Improved Hydration: Enhanced skin moisture.

• Youthful Radiance: Firmer, revitalised appearance.

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​At Dewdrop Aesthetics, we proudly offer a range of polynucleotide treatments, including:

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PLINEST

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What is PLINEST?

PLINEST is a polynucleotide-based product used for skin rejuvenation, repair, and regeneration.

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How does PLINEST work?

Derived from purified salmon DNA, PLINEST utilises the unique properties of polynucleotides to improve skin health and appearance. PLINEST works by delivering high-quality polynucleotides directly to the skin, triggering several biological processes that lead to skin regeneration and rejuvenation:

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• Hydration and Moisture Retention: Polynucleotides attract water molecules, significantly improving skin hydration and maintaining optimal moisture levels. This hydration effect helps to plump the skin, reducing the appearance of fine lines and wrinkles.

• Fibroblast Activation: PLINEST stimulates fibroblasts, the key cells involved in collagen and elastin production. This stimulation enhances skin elasticity and firmness, giving the skin a more youthful and toned appearance.

• Anti-Inflammatory and Antioxidant Properties: Polynucleotides have strong anti-inflammatory and antioxidant properties that help reduce skin inflammation and neutralise free radicals. This leads to improved skin texture and tone and a reduction in signs of aging.

• Cell Repair and Regeneration: The polynucleotides in PLINEST facilitate cell repair and regeneration by providing the necessary building blocks for nucleic acid synthesis. This process supports the natural healing and rejuvenation of damaged skin cells.

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Formulations of PLINEST

PLINEST is available in different formulations to target specific skin concerns and provide customised treatments:

• PLINEST Classic: A standard formulation designed for overall skin rejuvenation, hydration, and anti-aging effects. It is suitable for all skin types and can be used on the face, neck, and décolletage. 40 mg of polynucleotides (20mg/ml) in a 2ml syringe. 

• PLINEST Fast: A more concentrated formulation that provides quicker results for skin lifting and tightening. It is ideal for patients looking for faster improvement in skin elasticity and firmness.

• PLINEST Body: This formulation is specifically designed for body treatments to address skin laxity, stretch marks, and cellulite in areas such as the arms, thighs, abdomen, and buttocks.

• PLINEST Eye: A specialised formulation for the delicate under-eye area, focusing on reducing dark circles, puffiness, and fine lines. 15 mg of polynucleotides (7.5mg/ml). Comes in a 2ml syringe. 

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VITARAN: 

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What Is VITARAN?

VITARAN is an injectable bio-revitaliser. It belongs to the polynucleotide family, renowned for its regenerative properties. VITARAN is CE-marked and undergoes rigorous quality control.

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How Does VITARAN Work?

Derived from 100% filtered fragments of salmon DNA, VITARAN actively stimulates fibroblasts in the skin. These fibroblasts play a crucial role in collagen and elastin production. By aiding cellular stimulation and regeneration, VITARAN repairs the skin’s natural barrier.

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Treatment Areas and Formulations:

• VITARAN I: Suited for addressing periocular wrinkles in the delicate under-eye area. Polynucleotide gel with a concentration of 20 mg/ml. Comes in a 1ml syringe. 

• VITARAN II: Tailored for use on various facial areas, scars, and even the neck, hands, and chest. 2ml syringe - 40mg of polynucleotides. 

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Both formulations share exceptional quality, offering a natural solution for skin improvement.

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PLENHYAGE XL: 

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What Is Plenhyage XL? 

Plenhyage XL is an injectable skin treatment designed to promote tissue repair and rejuvenation.

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How Does Plenhyage Work?

Plenhyage XL is a gel made from polymerised polynucleotides. These polynucleotides actively stimulate fibroblast cells, encouraging cell turnover and collagen production. Plenhyage XL enhances skin elasticity and provides deep hydration.

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​Applications:

• Versatile: Suitable for various concerns, including acne scarring, hyperpigmentation, and rosacea.

• Treatment Areas: Can be used on the face, neck, décolletage, inner arms, thighs, and knees.

• Unique Benefits: Effective for challenging areas like the neck and under the eyes.

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Formulations:

• Medium (20mg/ml): Treats less severe aging and dark circles. 40mg of Polynucleotides per 2ml Syringe. 

• Strong (25mg/ml): Targets deeper wrinkles, acne scars, and body areas like hands and knees. Comes in 2ml syringe therefore has a high concentration of 50mg of polynucleotides. 

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NUCLEOFILL:

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What Is Nucleofill?

Nucleofill contains high molecular weight polynucleotide chains derived from salmon DNA. 

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How Does Nucleofill Work?

Nucleofill works with three main objectives:

• Lifting: Provides a lifting effect.

• Anti-Oxidant: Offers antioxidant benefits.

• Hydrating: Deeply hydrates the skin.

 

Formulations of Nucleofill:

• Nucleofill Soft Plus Eyes: Renews and refreshes the delicate skin around the eyes, brightens and firms the eye area, and reduces fine lines and wrinkles. 7.5mg/ml of polynucleotides therefore a 2ml will have 15mg. 

• Nucleofill Strong: Targets skin rejuvenation, bio-restructures the skin, contains polynucleotides for lasting hydration and collagen production, and is suitable for various areas of the face. It addresses deeper wrinkles and rejuvenates challenging areas by activating bio-regeneration at both the dermal and deeper tissue levels. 25mg per 1ml. A 1.5ml syringe will have 37.5mg. 

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How Many Treatments Are Recommended?

 

For best results, it is recommended to perform a series of 3 treatments with an interval of 20 days apart. You’ll notice a gradual improvement in your skin quality as the tissues regenerate. Most people see a difference after 3-4 weeks, but keep in mind that this is a regenerative treatment, so things will continue to improve. For full results, expect to see the best outcome around 3 months later. For the best results repeat your treatment after 6-12 months. 

 

Treatment & Events

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 Polynucleotide treatments are typically administered:

1. Preparation: Before the treatment begins, a local anesthetic cream is applied to numb the area. This ensures the comfort of our client during the procedure.

2. Injection: The polynucleotides, which are long chains of DNA, are then injected into the targeted area. This is done using a fine needle or a blunt-ended tube, known as a cannula. The injection is very superficial, meaning it’s just below the surface of the skin. There will be a slight pain, stinging during injections, minor bleeding, bruising in the treatment area may occur, swelling and redness. Several injections are needed to spread the treatment in the area of concern. After injections, your skin may have raised bumps that look like little ant bites, this is normal and usually settles within 24/48 hours. 

3. Absorption: Once injected, the DNA fragments are slowly absorbed into your skin without leaving any lumps. They integrate within your skin and start signaling your skin in various ways.

4. Stimulation: The polynucleotides stimulate fibroblast cells to multiply in number and boost their activity. As cell renewal improves, so will collagen production, hydration levels, and skin glow. Your skin becomes more resilient with improved elasticity and wrinkles start diminishing.

5. Healing: Polynucleotides function as wound healing agents, signaling your skin to intensely repair. This helps improve scars, reduce stretch marks, and improve skin texture concerns.

6. Results: The result of the treatment depends on a variety of factors, including the degree of your skin ageing prior to the treatment, your skin’s ability to regenerate good quality tissue when stimulated, and your lifestyle.

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Polynucleotides can be used to treat various hair conditions, including hair damage and hair loss. If you’re interested in these treatments or have a specific brand preference, we encourage you to reach out to us. We can schedule a session for your hair treatment and discuss your preferences in more detail.

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Another remarkable aspect is that the risk of vascular occlusion (a blocked artery) is virtually nonexistent. Here’s why:

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1. DNA Fragments in Water:

   • The treatment involves tiny DNA fragments suspended in water.

   • These fragments closely mimic the components already present in your bloodstream. As a result, they seamlessly integrate without causing blockages.

2. No Gel, No Obstruction:

   • Unlike some treatments that use gel-based substances, this method avoids any chance of blockages. The absence of gel ensures a smooth and safe experience.  

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In summary, the use of DNA fragments in water offers both effectiveness and safety, minimizing any risk of vascular issues.

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There is a small risk of bruising or swelling to the treated areas which can develop in the hours/days afterwards, and it is therefore advisable that the treatment is performed at least 2 weeks before any event. This can be discussed further to help you plan when to have your treatment.

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The difference between Skin Boosters and Polynucleotides:

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Skin Boosters

Mechanism:

• Skin boosters, such as Profhilo, primarily focus on boosting moisture levels in the skin.

• They contain hyaluronic acid, which provides hydration and plumping effects.

Effects:

• Immediate improvement in skin texture due to increased hydration.

• Mild stimulation of collagen production.

Areas of Application:

• Typically used for general skin hydration, especially in areas like the face, neck, and hands.

Pros:

• Quick results.

• Safe and well-tolerated.

• Suitable for various skin types.

Cons:

• Requires multiple sessions for optimal results.

• Effects are temporary and need maintenance.

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Polynucleotides (PNs)

Mechanism:

• PNs are derived from salmon or trout sperm DNA.

• They actively signal cells to produce collagen and elastin.

• Repair damaged skin cells through the use of DNA fragments.

Effects:

• Long-lasting improvements in skin texture and elasticity.

• Address areas where many skin boosters cannot reach (e.g., eyes, lips, forehead).

Areas of Application:

• Effective for various facial areas, including under the eyes, neck, jawline, and cheekbones.

• Revolutionising under-eye treatments.

Pros:

• Natural skin rejuvenation.

• Significant improvement in hydration.

• Biocompatible and safe.

Cons:

• Contains animal-derived ingredients (not suitable for vegetarians, vegans, or fish-allergic individuals).

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Summary: While skin boosters provide immediate hydration, polynucleotides offer deeper repair and longer-lasting effects.

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POLYNUCLEOTIDES CONTRAINDICATIONS

Unfortunately some treatments are not suitable for everyone.  
Some include: Fish allergy, Undergoing chemotherapy, skin cancer pregnant/nursing, HIV/AIDS,  rosacea, Solar Keratosis, Acne Vulgaris Stage III-IV, Anticoagulants / Blood thinners (including but limited to Warfarin or aspirin), diabetic, autoimmune disease,  taking roaccutane, prone to keloid scarring, active cold sore or acne, sensitivity to HA, allergies to needles, any infection, areas where long lasting filler has been used.

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